Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0344948
PubChem CID
Molecular Formula
C16H18BrN3O
Molecular Weight
348.244 g/mol
Synonyms/Alias
[urea TRPV1 antagonist; 11; CHEMBL121222; SCHEMBL9942096; BDBM20478; 1-(2-bromophenyl)-3-{2-[(3-methylphenyl)amino]ethyl}urea]
InChI Key
ZHIILYBYAZTTPK-UHFFFAOYSA-N
InChI
InChI=1S/C16H18BrN3O/c1-12-5-4-6-13(11-12)18-9-10-19-16(21)20-15-8-3-2-7-14(15)17/h2-8,11,18H,9-10H2...
IUPAC Name
1-(2-bromophenyl)-3-[2-(3-methylanilino)ethyl]urea
CAS Number
459429-39-1

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

39 40 0 0 0 0 0 0 0 0999 V2000
-6.6802 0.8257 0.2146 C 0 0 0 0 0 0 0 0 0 0 0 0
-5.1809 0.8459 0.1672 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.4706 -0.301...

Experimental Data

Activity Data

Target Ion Channel
Transient receptor potential cation channel subfamily V member 1
Uniprot Accession Number
Function
Antagonist
Species
Cavia porcellus (Guinea pig)
IC50
N/A (Not available)
EC50
EC50: >158 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.2
Holding Potential
Not specified
Temperature
Room Temperature
Test Method
Fluorometric Imaging Plate Reader (FLIPR) Membrane Potential Assay
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
21
Rotatable Bonds
5
logP
3.9911
Complexity
90.8321
TPSA (Ų)
53.16
H-Bond Donors
3
H-Bond Acceptors
2
Ring Count
2
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